The Subversives discussion
For the Non-Fic Freaks Out There...
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I think Hawking's book "A Brief History of Time" had brought lofty physical theories and phenomena to the layman, and would have been a good contender for the Science book for all time top spot.

Books mentioned in this topic
Sense and Second-Degree Murder (other topics)Beowulf: A Verse Translation (other topics)
Nineteen Eighty-Four (other topics)
The greatest 100 Science books of all time, according to Discover magazine.
Kuhn's book (see group bookshelf) got honorable mention, as did Hawking.
My own favorite "The Cartoon Guide To Physics" didn't make the cut.