There was an observed correlation between low blood levels of these antioxidant nutrients and a higher incidence of cancer and heart disease, and a plausible mechanism for how they could have been preventive, but when you gave them as supplements, it turned out that people were no better off or were possibly more likely to die. That is, in some respects, a shame, as nice quick fixes are always useful, but there you go. It means that something funny is going on, and it will be interesting to get to the bottom of it and find out what. More interesting is how uncommon it is for people even to be
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