Chronic or repeated stress can also disrupt the neuroendocrine balance. Stress activates the hypothalamic-pitiutary-adrenal (HPA) axis, which secretes cortisol and activates the body’s immune system. In the usual acute stress situation, this system activates the “fight-flight” mechanisms of the body in a productive way. An internal feedback mechanism acts like a thermostat to then turn down the axis and return the body to equilibrium. However, ongoing stress dismantles the regenerative circuit and the stress alarms continue unabated, inflicting negative impact on the body, including shrinkage
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