Wyatt was drawn to architecture as a young man and spent six years in Italy studying architectural drawing. In 1770, aged just twenty-four, he designed the Pantheon, an exhibition hall and assembly room on Oxford Street in London, which was loosely modeled on the ancient building of the same name in Rome. Horace Walpole thought it “the most beautiful edifice in England.” In 1931, the building, still beautiful though much altered, was torn down to make way for a Marks and Spencers department store.