immensely stressful. Not surprisingly, anxiety disorders are associated with chronically overactive stress-responses, and with increased risk of many of the diseases that fill the pages of this book (anxiety-prone rats, for example, have a shortened life span). However, glucocorticoid excess is not the usual response. Instead, it’s too much sympathetic activation, an overabundance of circulating catecholamines (epinephrine and norepinephrine).