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glucocorticoid secretion is consistently elevated during withdrawal, into the range where it depletes dopamine. And what happens if you add additional stress on top of that? All that the extra glucocorticoids can do in this scenario is make the dopamine depletion even worse. Thus increasing the craving for that drug-induced boost of dopamine.
Why Zebras Don't Get Ulcers: The Acclaimed Guide to Stress, Stress-Related Diseases, and Coping
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