This is terrific. I believe we have a stress-related disease on our hands. But some critical questions remain to be asked. One concerns why it is that after three or so bouts of major depression the stress-depression link uncouples. This is the business about depressive episodes taking on an internal rhythm of their own, independent of whether the outside world is actually pummeling you with stressors. Why should such a transition occur? At present, there’s a lot of theorizing but very little in the way of actual data. But the most basic question remains, why do only some of us get depressed?
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