Suppose that something truly stressful occurs, and a maximal signal to secrete CRH, ACTH, and glucocorticoids is initiated. If the stressor ends after, say, ten minutes, there will cumulatively be perhaps a twelve-minute burst of CRH exposure (ten minutes during the stressor, plus the seconds it takes to clear the CRH afterward) and a two-hour burst of exposure to glucocorticoids (the roughly eight minutes of secretion during the stressor plus the much longer time to clear the glucocorticoids). So the period where glucocorticoid levels are high and those of CRH are low is much longer than the
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