In addition, there’s now all that glucose and fatty acid circulating in the bloodstream—oleaginous hoodlums with no place to go, and soon there’s atherosclerotic trouble there as well. The circulating stuff gums up the blood vessels in the kidneys, causing them to fail. The same can occur in the eyes, causing blindness. Blood vessels elsewhere in the body are clogged, causing little strokes in those tissues and, often, chronic pain.