In February 1911, Quanah was returning by train from a visit to some of his Cheyenne friends, reportedly to seek a cure at a peyote meeting. He knew he was sick. Traveling with his number one wife, the childless To-nar-cy, he rode the train with his head bowed and lips trembling. When he arrived home in Cache, he was taken to his house by his white son-in-law Emmet Cox. He died there on February 23 of rheumatism-induced heart failure.