Spark: The Revolutionary New Science of Exercise and the Brain

by John J. Ratey

head comparison until researchers at Duke University took up the task in 1999. In a landmark study affectionately called SMILE (Standard Medical Intervention and Long-term Exercise), James Blumenthal and his colleagues pitted exercise against the SSRI sertraline (Zoloft) in a sixteen-week trial. They randomly divided 156 patients into three groups: Zoloft, exercise, or a combination of the two. The exercise group was assigned to supervised walking or jogging, at 70 to 85 percent of their aerobic capacity, for thirty minutes (not including a ten-minute warm-up and a five-minute cool-down) three times a week. The results? All three groups showed a significant drop in depression, and about half of each group was completely out of the woods—in remission. Another 13 percent experienced fewer symptoms but didn’t fully recover.

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