The Immortal Life of Henrietta Lacks

by Rebecca Skloot

to grow new cell lines. And in fact, “very few [new human cell lines] have been reported since.” Not only that, he said, but there had been no new examples of “so-called spontaneous transformed human cell cultures” since. Everyone in the audience knew what that meant. On top of saying they’d possibly wasted more than a decade and millions of research dollars, Gartler was also suggesting that spontaneous transformation—one of the most celebrated prospects for finding a cure for cancer—might not exist. Normal cells didn’t spontaneously become cancerous, he said; they were simply taken over by HeLa. Gartler concluded his talk by saying, “Where the investigator...

The room sat silent, dumbfounded, until T. C. Hsu, the chair of Gartler’s conference session, spoke. Hsu was the University of Texas geneticist whose earlier work with HeLa and other cells had made it possible to discover the correct number of human chromosomes. “A few years ago I voiced some suspicion about cell-line contamination,” Hsu said. “So I am happy about the paper by Dr. Gartler and am also sure he has made many people unhappy.” He was right, and those people quickly began asking questions. “How long did you keep them in your laboratory?” one scientist asked, suggesting that Gartler had contaminated the cells himself after they arrived in his...

could have occurred while they thawed. Gartler said that didn’t matter—the cells didn’t have to be thawed to be tested. Another scientist wanted to know if the similarity Gartler was seeing between cell lines was just the effect of spontaneous transformation making all cells act the same. Eventually Robert Stevenson of the Cell Culture Collection Committee spoke up, saying, “It looks like more detective work is needed to see … whether we are going to have to start all over again to isolate some new human cell lines.” Hsu stepped in and said, “I would like to give particular priority to those who initiated the cell lines, whom Dr. Gartler has attacked. If there is any defense, we would like to hear it.” Harvard’s Robert Chang—whose widely used Chang Liver Cell line was listed as a HeLa contaminant on Gartler’s chart—glared from his seat. Chang had used those cells to discover enzymes and genes specific to liver cells. If Gartler was right and the cells were actually from Henrietta’s cervix, Chang’s liver research using them was worthless. Leonard Hayflick had an especially personal connection with his cell line, WISH, which Gartler had listed as contaminated: he’d grown it using ...

genetic marker found only in black people, he’d called his wife during the break to ask if he was, in fact, his daughter’s father. “She assured me that my worst fears were unfounded,” Hayflick said. The room erupted in laughter, and no one said anything else publicly about Gartler’s findings. But a few people took Gartler seriously: before leaving the conference, Stevenson met several of the top cell culturists for lunch. He told them to go back to their labs after the conference and start testing cells for the G6PD-A genetic marker, to see how widespread this problem might be. Many of their cell lines tested positive, including the skin cells George Hyatt had transplanted onto a soldi...

it, the same thing was happening in laboratories around the world. Still, many scientists refused to believe HeLa contamination was real. After the conference where Gartler dropped what became known as “the HeLa bomb,” most researchers kept right on working with the cells he’d said were contaminated. But Stevenson and a few other scientists realized the potential scope of the HeLa contamination problem, so they began working to develop genetic tests that could specifically identify HeLa cells in cul...

“Scientists can even grow corneas now,” I told him, reaching into my bag for an article I’d clipped from a newspaper. I handed it to him and told him that, using culturing techniques HeLa helped develop, scientists could now take a sample of someone’s cornea, grow it in culture, then transplant it into someone else’s eye to help treat blindness.

The Lackses aren’t the only ones who heard from a young age that Hopkins and other hospitals abducted black people. Since at least the 1800s, black oral history has been filled with tales of “night doctors” who kidnapped black people for research. And there were disturbing truths behind those stories.

Some of the stories were conjured by white plantation owners taking advantage of the long-held African belief that ghosts caused disease and death.

To discourage slaves from meeting or escaping, slave owners told tales of gruesome research done on black bodies, then covered themselves in white sheets and crept around at night, posing as spirits coming to infect black people with disease or steal them for research. Those s...

Many doctors tested drugs on slaves and operated on them to develop new surgical techniques, often without using anesthesia. Fear of night doctors only increased in the early 1900s, as black people migrated north to Washington, D.C., and Baltimore, and news spread that medical schools there were offering money in exchange for bodies. Black corpses were routinely exhumed from graves for research, and an under ground shipping industry kept schools in the North supplied with black bodies from the South for anatomy courses. The bodies sometimes arrived, a dozen or so at a time, in barrels labeled turpentine.

Because of this history, black residents near Hopkins have long believed the hospital was built in a poor black neighborhood for the benefit of scientists—to give them easy access to potential research

patients. In 1969, a Hopkins researcher used blood samples from more than 7,000 neighborhood children—most of them from poor black families—to look for a genetic predisposition to criminal behavior. The researcher didn’t get consent.

If our mother so important to science, why can’t we get health insurance?”

(Her syphilis, it turns out, could have been a factor as well—syphilis can suppress the immune system and allow cancer to spread faster than normal.)

She’d read in the paper about the syphilis study at Tuskegee, which had just been stopped

by the government after forty years,

“It was done eight years ago in New York City by Dr. Chester Southam, a cancer specialist who injected live cancer cells into chronically ill elderly patients.”

Nearly seven years after Moore originally filed suit, the Supreme Court of California ruled against him in what became the definitive statement on this issue: When tissues are removed from your body, with or without your consent, any claim you might have had to owning them vanishes. When you leave tissues in a doctor’s office or a lab, you abandon them as waste, and anyone can take your garbage and sell it. Since Moore had abandoned his cells, they were no longer a product of his body, the ruling said. They had been “transformed” into an invention and were now the product of Golde’s “human ingenuity” and “inventive effort.”

There are more than one hundred strains of HPV in existence, thirteen of which cause cervical, anal, oral, and penile cancer—today, around 90 percent of all sexually active adults become infected with at least one strain during their lifetimes. Throughout the eighties, using HeLa and other cells, scientists studied HPV infection and how it causes cancer. They learned that HPV inserts its DNA into the DNA of the host cell, where it produces proteins that lead to cancer. They also found that when they blocked the HPV DNA, cervical cancer

Research into HPV eventually uncovered how Henrietta’s cancer started: HPV inserted its DNA into the long arm of her eleventh chromosome and essentially turned off her p53 tumor suppressor gene. What scientists still haven’t figured out is why this produced such monstrously virulent cells both in and out of Henrietta’s body, especially since cervical cancer cells are some of the hardest of all cells to culture.

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal.

They also knew that there was a string of DNA at the end of each chromosome called a telomere, which shortened a tiny bit each time a cell divided, like time ticking off a clock. As normal cells go through life, their telomeres shorten with each division until they’re almost gone. Then they stop dividing and begin to die. This process correlates with the age of a person:

the older we are, the shorter our telomeres, and the fewer times our cells have left to divide before they die.

By the early nineties, a scientist at Yale had used HeLa to discover that human cancer cells contain an enzyme called telomerase that rebuilds their telomeres. The presence of telomerase meant cells...

This explained the mechanics of HeLa’s immortality: telomerase constantly rewound the ticking clock at the end of Henrietta’s chromosomes...