In its most extreme form, this muscle loss is called sarcopenia,18 as noted in chapter 11. Someone with sarcopenia will have low energy, feelings of weakness, and problems with balance. Sarcopenia is a prime marker for a broader clinical condition called frailty,19 where a person meets three of these five criteria: unintended weight loss; exhaustion or low energy; low physical activity; slowness in walking; and weak grip strength (about which more soon).