Almost a century earlier, the Italian scientist Amedeo Avogadro (1776–1856) had developed the hypothesis—correct, as it turned out—that equal volumes of any gas, when measured at the same temperature and pressure, will have the same number of molecules. That led to a difficult quest: figuring out just how many this was. The volume usually chosen is that occupied by a mole of the gas (its molecular weight in grams), which is 22.4 liters at standard temperature and pressure. The number of molecules under such conditions later became known as Avogadro’s number. Determining it precisely was, and
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