The smallpox vaccine is safe, and it is effective at preventing smallpox disease. Let’s see what safe means to the CDC: Serious Side Effects of Smallpox Vaccine Heart problems Swelling of the brain or spinal cord Severe skin diseases Spreading the virus to other parts of the body or to another person [huh?] Severe allergic reaction after vaccination Accidental infection of the eye (which may cause swelling of the cornea causing scarring of the cornea, and blindness)

