The physician should suspect TTP if three of five of the following symptoms are present (LMNOP): 1. Low platelet count (thrombocytopenia) 2. Microangiopathic hemolytic anemia with schistocytes (severe, often with jaundice) 3. Neurologic changes (delirium, seizure, stroke, ↓ consciousness, ↓ vision) 4. “Obsolete” (impaired) renal function (acute kidney injury [AKI]) 5. Pyrexia (fever)
