one of the early signs that your cells are becoming metabolically inflexible as when you get “hangry,” especially if it has been only a few hours since you last ate. This is a telltale sign that your cells are not making that switch over to fat burning. Healthy mitochondria will easily adapt to declining glucose levels while waiting for the ketone surge. This metabolic switch will feel effortless, allowing you to go longer without food while it takes time for the liver to supply ketones. Unhealthy mitochondria, on the other hand, will struggle while waiting for that switch.