Well, it turns out that your gut microbes have a direct connection to your liver via your portal vein.2 When in a fasted state, these microbes will send a signal to the liver to switch over to the fat-burning energy system. If these microbes are missing, then that signal may never get to the liver, making it difficult for you to stay in a fasted state. I see this a lot in women who have been on multiple rounds of antibiotics and have lost much of their microbial diversity. They will struggle to get into ketosis because these missing microbes aren’t sending signals to the liver to switch over.
