Through her third marriage, Lucrezia finally escaped her interfering family (her father had annulled her first marriage, and her brother had murdered her second husband) by ending up in the city-state of Ferrara as wife of Alfonso d’Este, who would become the ruling duke. The d’Este family had not wanted the marriage, fearful of her reputation as a sex fiend and a poisoner, but they had finally caved in to the intimidation and generous financial offers of the pope. But once installed as duchess, Lucrezia made herself universally popular, serving as patron to artists and poets, and reigning
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