Assuming the microbes in question start out with a clean bill of health and genetic fitness, a suitable and well-maintained culture should allow for their happy, healthy growth and proliferation. If the same organisms begin showing pathologies at unprecedented rates, or fail to thrive, it’s either because the culture has become contaminated or because it was the wrong mixture in the first place. Whichever the case, we could rightly call this a toxic culture—unsuitable for the creatures it is meant to support. Or worse: dangerous to their existence. It is the same with human societies.