The Song of the Cell: An Exploration of Medicine and the New Human

by Siddhartha Mukherjee

Scientists at Verve have devised ways to insert catheters into the arteries leading to the liver. (The dexterity that Sek learned from decades of practice in cardiology helped.) These catheters will deliver gene-editing enzymes, loaded inside tiny nanoparticles, to the organ. Once these particles off-load their cargos inside the liver cells, the gene-editing enzymes will change the scripts of genes that aid and abet cholesterol metabolism, thereby drastically decreasing the amount of circulating cholesterol in the blood—in essence, activating the LDL metabolizing pathways. It’s a one-and-done infusion. Once the genes have been altered, they are altered for life. If successful, Verve’s gene therapy would transform you into a human with permanently lowered cholesterol level, permanently protected from coronary artery disease, permanently safe from myocardial infarction.