There are mysteries beyond mysteries. Engineered T cells are potently active against leukemias and lymphomas, but fail against ovarian and breast cancer. Why? The kind of immunotherapy used in Sam’s case eliminated the tumors in his skin, but not in his lungs. Why? As one of my own postdoctoral researchers discovered, our method of insulin depletion, via diet, decelerated endometrial and pancreatic cancers but accelerated the development of some leukemias in mice. Why? We don’t know what we don’t know.
