Depression is a flaw in love. But more fundamentally, perhaps, it is also a flaw in how neurons respond—slowly—to neurotransmitters. It is not just a wiring problem, Greengard believes, but rather a cellular disorder—of a signal, instigated by neurotransmitters, that somehow malfunctions and creates a dysfunctional state in a neuron. It is a flaw in our cells that becomes a flaw in love.