Insulin resistance takes on a life of its own, though. The pancreas responds to insulin resistance by pumping out more insulin. If a little isn’t working, then send out a lot. That helps! But the problem is that higher levels of insulin usually make insulin resistance even worse over time. They drive hunger and weight gain. And one of the problems with higher and higher levels of insulin is that insulin resistance alone inhibits mitochondrial biogenesis, compounding the metabolic problem.17
