Mitochondria also play an essential role in immune system function.16 This includes fighting off viruses and bacteria, but it also includes low-grade inflammation, something that has been found in most metabolic and mental disorders to some degree. Mitochondria help regulate how immune cells engage with immune receptors. When cells are highly stressed, they often release components of mitochondria, which serve as a danger signal to the rest of the body, one that activates chronic, low-grade inflammation.17