They mutate often due to ROS and the lack of protection of mitochondrial DNA. Wallace argued that the brain is the organ that will be most affected by a problem with energy production by mitochondria. He argued that different parts of the brain might fail first—likely because they are more sensitive to energy deprivation than others. This makes sense, given that most machines do have “weakest links.” The brain is likely the same. So, a small amount of energy deprivation might result in ADHD or depression and a larger amount of energy deprivation might result in other disorders, such as
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