Never Enough: The Neuroscience and Experience of Addiction

by Judith Grisel

Repeated administration of any drug that influences brain activity leads the brain to adapt in order to compensate for the changes associated with the drug.

And in the United States during the period between 2006 and 2010, excessive alcohol use was responsible for close to 90,000 deaths a year, including one in ten deaths among adults aged twenty to sixty-four, translating to 2.5 million years of potential life lost. More than half of these deaths and three-quarters of the years of potential life lost were due to binge drinking.

Who and what we encounter on a daily basis, including our relationships, workplaces, neighborhoods, media, and opportunities, all weigh in to influence who we are and what we become.

the aim of science is not to open a door to infinite wisdom but rather to set a limit on infinite ignorance.

The story of this endeavor—bravado, surprise, then humility—is more or less the story of science in general and a microcosm of my personal path.

“We can’t fix what we won’t face,”

as a society we’re suffering from depth deprivation.

We affect each other, including each other’s neurobiology, neurochemistry, and behavior, in ways that are direct and profound. As