the brain is so well organized to counteract perturbations that it uses its exceptional learning skills to anticipate disruptions, rather than wait for the changes themselves, and begins to dampen drug effects before the drug has even been delivered. Suppose you enjoy a few drinks with friends at a neighborhood bar every Friday after work, as you have been doing for years. It turns out that the predictability of this routine leads to changes in your experience. First, the alcohol will have less effect on you in that particular place and time and with those particular friends than it would have
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