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I now know that the delay happens because of sponge-like binding proteins that are floating around in the blood, to which THC molecules are attracted like magnets; they can’t affect the brain until these proteins are fully saturated. Once all the binding sites are occupied, though, THC can finally be distributed to the brain. I’ve heard that some people don’t get any effects from the drug, and though this is theoretically possible, it’s extremely unlikely. More likely they need to smoke a little more.
Never Enough: The Neuroscience and Experience of Addiction
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