When there are too many free radicals to be neutralised, our body is said to be in a state of oxidative stress. Oxidative stress is a driver of heart disease, type 2 diabetes, cognitive decline and general ageing. And fructose increases oxidative stress even more than glucose alone. That’s one of the reasons that sweet foods (which contain fructose) are worse than starchy foods (which don’t). Too much fat can also increase oxidative stress.