We can measure no aspect of a particle without in some fashion interacting with it, and that interaction changes the particle’s nature. This becomes dramatically obvious at the quantum level: for anything to be literally seen requires the object of our interest to be struck by a photon. That collision alters the system that is observed. With particles smaller than can be seen by light, we may use electromagnetic waves with much smaller wavelength, but such waves have inevitably greater energy, and interfering with a particle with a high energy beam changes the particle more radically.