An organ that is transplanted had to be taken out of another living being—to do that it had to be separated from it. Usually with sharp tools. This whole process is likely to have caused small wounds—what do wounds inside the body trigger? Inflammation, which then attracts the Innate Immune System. And if things go wrong, the Adaptive Immune System gets called right to the edges of the new life-saving organ and can call in more cells that check out the display windows only to find that they are not yours. This is the unfortunate reason that after you receive a donated organ, you need to be on
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