Now, after the exposure to the crabmeat, a lot of IgE Antibodies that are able to attach to the crabmeat allergen are in your system. But IgE Antibodies by themselves would not be problematic as they are not particularly long-lived and dissolve after a few days. They need help to become a problem from a special cell in your skin, lungs, and intestines that is especially receptive to IgE Antibodies: the Mast Cell.