The truth is we don’t know yet why some people produce a lot of IgE Antibodies when they come in contact with certain allergens and others don’t. But while we don’t know for sure why some people are more affected than others, we think we know what IgE Antibodies were originally supposed to do: They are the immune system’s superweapons against large parasites that are too big for your phagocytes, your Macrophages, and your Neutrophils to swallow. Especially one of the most horrible parasites: Parasitic worms. A menace humanity has had to deal with for millions of years.