Lipoic acid: We’ve seen a good study showing that 5% lipoic acid can effectively reduce signs of photoaging. Given the high use level, we wouldn’t recommend choosing a product that has lipoic acid lower than the fifth position in an ingredient list. CoQ10: This is the abreviation for “coenzyme Q10,” also known as ubiquinone. It is a natural and integral part of your cell function and is an important part of your skin’s natural defense system against outside aggressors. Topically, you need about 0.5% CoQ10, ideally in combination with vitamin E.