Broadly, the leukocytic pyrogen was a kind of mediator, communicator. Interleukin-1, the first interleukin, was born. Dr. Dinarello might fairly be called its midwife. Armed with this knowledge alone, you’re on your way to earning a bachelor’s degree in immunology. The story doesn’t quite end there. Maybe the most important part was yet to come, and it would make Dr. Dinarello quite a controversial figure.

