The current hypothesis was that the Kent variant, now called B.1.1.7, had a mutation that switched an amino acid in the spike protein, allowing it to bind more tightly to the body’s ACE2 receptors. “That means it takes less virus to infect you,” Brooks said. “That tighter binding also means that it can replicate more efficiently.” Once infected with the new variant, a person will be shedding more virus than someone infected with another variant. “It’s a wicked cycle,” Brooks observed. B.1.1.7 quickly spread to dozens of countries. Historically, novel viruses have declined in mortality as they
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