If we’re burning a lot of fat, whether we’re on an extremely low-carb diet or starving, some of the acetyl CoA generated will be converted to molecules called ketones. Most ketone production occurs in the liver. Ketones are sort of a traveling version of acetyl CoA, and can travel in the bloodstream to other cells, be reconverted to acetyl CoA, and used to generate ATP. Like a lot of metabolic conversion, most ketone production is done in the liver, but they are used throughout the body. This is the pathway that popular ketogenic diets engage, promoting a system of eating all fats and proteins
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