A study in the American Journal of Clinical Nutrition found that replacing saturated fats with high-glycemic index carbs was associated with a 33 percent increase in heart attack risk.21 Because most people replace saturated fat with exactly these kinds of processed, high-glycemic (high-sugar) carbs (e.g., breads, cereals, and pasta), the conventional wisdom to cut out saturated fat and consume lots of carbs instead is starting to look like an increasingly boneheaded notion.