Despite the dangers, there could be benefits if biotech followed this route. During a pandemic, it would be useful if societies could tap the biological wisdom and innovation of crowds. At the very least, it would be good to have citizens who could test themselves and their neighbors at home. Contact tracing and data collection could be crowdsourced. Today, there is a sharp line dividing officially sanctioned biologists from do-it-yourself hackers, but Josiah Zayner is dedicated to changing that. CRISPR and COVID could help him blur those lines.