No man, barring the damned Kwisatz Haderach himself and his Tyrant son, had ever known the particulars of this Bene Gesserit secret. Both of those monsters had felt the Agony. Two disasters! No matter that the Tyrant’s Agony had worked its way inward a cell at a time to transform him into a sandworm symbiote (no more original worm, no more original human). And Muad’Dib! He dared the Agony and look what came of that!