Mitochondria are inhibited by uric acid, low folate, and fructose, which both cause mitochondria to be overwhelmed in order to divert energy to fatty acid and triglyceride production. Signs of poor mitochondrial function are high uric acid and high homocysteine. Signs of liver fat are high ALT and high fasting insulin. Signs of poor peripheral clearance of fat are a high triglyceride and a low HDL.

