Part of the big fuss about Prozac is that it works on just one neurotransmitter, serotonin. Prozac and its relatives—Paxil, Zoloft, etc.—are called “selective serotonin-reuptake inhibitors,” or SSRIs. No one knows why this selectivity is such an advantage in treating certain difficulties. But scientists are now trying to get to know serotonin better.