In a short paper published in 1967, Sakharov laid out three conditions that he demonstrated must be met in order for a perfectly balanced collection of matter and antimatter to become dominated by matter. Although they can be complicated to describe in their full technical glory, these conditions can be paraphrased roughly as follows: There must exist some kind of interaction between particles that can change the total number of quarks minus the total number of antiquarks. Nature must have a bias in these interactions that favors the creation of matter over antimatter, or the destruction of
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