As a neuroscientist, I’ve wondered why some people seem to age better than others. Is it genetics, personality, socioeconomic status, or just plain dumb luck? What is going on in the brain that drives these changes? What can we do to stem the cognitive and physical slowdown that accompanies aging? Many people thrive well into their eighties and nineties, while others seem to retreat from life, prisoners of their own infirmities, socially isolated and unhappy. How much control do we have over our outcomes, and how much is predetermined?