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Biochemist Jan van Deursen and his colleagues found a chemical marker that distinguishes certain senescent cells from healthy ones and then administered a drug called AP20187 that causes those cells to die. Drugs like this are called senolytics (combining the first part of the word senescence with lytic, which means destroying) and the proposed treatment is called senotherapy. Van Deursen found that clearance of these zombie cells in young mice delayed aging. In already aged mice, it slowed the progression of age-related disorders. Removing the senescent cells appears to jump-start some of the ...more
Successful Aging: A Neuroscientist Explores the Power and Potential of Our Lives
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