Acetaminophen (aka Tylenol) has been found to be the least effective for arthritis, but that makes sense—it is not an anti-inflammatory and is not interchangeable with, for example, ibuprofen (e.g., Advil and Motrin). Acetaminophen is a pain reliever and reduces fever. If you have a swollen ankle, it probably won’t help as much as an anti-inflammatory.
