The compassionate attitude and outlook are also related to experiencing less stress. You can choose not to be stressy—or learn how—and this can save your life. The HPA (hypothalamic-pituitary-adrenal) axis is an endocrine system that controls the secretion of stress hormones (glucocorticoids) including cortisol. Exposure to high levels of glucocorticoids can be particularly detrimental for the aging hippocampus and is associated with decrements in learning and memory.