The prefrontal cortex is also the first cortical region to show wear and tear as we get older. “That is why one of the most significant problems in older adults is the ability to keep track of thoughts and prevent stray ones from interfering,” says Art Shimamura. “Brain fitness as we age depends significantly on maintaining a healthy and active prefrontal cortex. The more we engage this brain region during daily activities, the better we will be able to control our thoughts and think flexibly.”