SSRIs—selective serotonin reuptake inhibitors. SSRIs cause whatever serotonin is in the brain to linger around the synapses longer—it’s as though you’re giving the brain more serotonin, but you’re just squeezing more mileage out of the serotonin that’s already there. A fad in these drugs resulted. SSRIs such as Prozac were widely prescribed for people with depression.